3. Aminoalkylindole: Members of aminoalkylindole group have different structures

from both the classical and non-classical cannabinoids. R-(+)-WIN 55,212-2 is

the most studied member of this group which has the similar intrinsic activity as

CP55940 and HU-210. However, it possesses higher CB2 affinity than CB1.

4. Eicosanoids: They are endogenous fatty acid amides. Endocannabinoids like

anandamide and 2-AG are classified as the members of this group. They have

lower affinity and relative intrinsic activity for CB2 receptor in comparison to

CB1 receptor. Two other compounds included in this group are virodhamine and

N-arachidonoyl dopamine (Table 12.1).

12.5

Pathophysiological Role of Cannabinoid System in Human

Diseases

Over the years, various preclinical researches have confirmed the involvement of

endocannabinoid system (ECS) components in different pathophysiological

conditions and diseases. In this section, we will discuss briefly the implications of

ECS components in different human diseases (Fig. 12.2).

Table 12.1 Ligands and their interaction with the receptors

S. no.

Ligand

CB1

receptor

CB2

receptor

Agonist

Antagonist

GPR55

receptor

agonist

1

Tetrahydrocannabinol

(THC)

✓

✓

✓

–

–

2

WIN 55,212-2

✓

✓

–

–

–

3

Cannabidiol (CBD)

✓

✓

–

✓

–

4

Arachidonyl-

2⁰-chloroethylamide

(ACEA)

✓

–

✓

–

–

5

Anandamide (AEA)

✓

✓

✓

–

✓

6

JWH015

–

✓

✓

–

–

7

AM251

✓

–

–

✓

✓

8

GW405,833 (GW)

–

–

–

9

JWH-133

–

✓

✓

–

✓

10

2-

Arachidonoylgylcerol

(2-AG)

✓

✓

✓

–

✓

11

CP 55940

✓

✓

✓

–

✓

✓(tick mark) represents the binding affinity of ligand toward the particular receptor

12

Emerging Role of Cannabinoid System Modulators in Treatment of Cancer

183